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Text-to-Speech (Python recipe) by Nelson Rush
ActiveState Code (http://code.activestate.com/recipes/114216/)

An example of using the MS Speech SDK to implement TTS (Text-To-Speech).

Python, 21 lines
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# speak.py
#
# Repeats what user types.
#
# Make sure you have MS Speech SDK installed
# and registered with the MakePy tool in PythonWin.
#
import sys
from win32com.client import constants
import win32com.client

speaker = win32com.client.Dispatch("SAPI.SpVoice")
print "Type word or phrase, then enter."
print "Ctrl+Z then enter (dos/win32) or Ctrl+D (unix) to exit."
while 1:
	try:
		s = raw_input()
		speaker.Speak(s)
	except:
		if sys.exc_type is EOFError:
			sys.exit()

This is fun, you could make a Dr. Sbaitso clone if you throw some Markov chains in.